1. What is the Sampson LDL Equation?

The Sampson equation is a novel method for calculating LDL cholesterol that provides more accurate results than the traditional Friedewald formula, especially in patients with low LDL levels or high triglycerides.

2. How Does the Calculator Work?

The calculator uses the Sampson equation:

Where:

• \( TC \) — Total cholesterol (mg/dL)
• \( HDL-C \) — HDL cholesterol (mg/dL)
• \( TG \) — Triglycerides (mg/dL)

Explanation: This equation provides a more accurate estimation of LDL cholesterol levels compared to traditional methods, particularly in patients with hypertriglyceridemia.

3. Importance of LDL Calculation

Details: Accurate LDL cholesterol measurement is crucial for cardiovascular risk assessment and guiding lipid-lowering therapy decisions.

4. Using the Calculator

Tips: Enter total cholesterol, HDL cholesterol, and triglycerides in mg/dL. All values must be valid and greater than 0.

5. Frequently Asked Questions (FAQ)

Q1: Why use Sampson instead of Friedewald formula?
A: The Sampson equation provides more accurate LDL estimates, especially when triglycerides are elevated (>400 mg/dL) or when LDL levels are very low.

Q2: What are optimal LDL cholesterol levels?
A: Optimal LDL is generally <100 mg/dL, though targets may vary based on individual cardiovascular risk factors.

Q3: When should lipid testing be performed?
A: Fasting samples (9-12 hours) are preferred for accurate triglyceride measurement, though non-fasting samples can be used for total and HDL cholesterol.

Q4: Are there limitations to this equation?
A: The equation may be less accurate in certain populations, such as patients with very high triglycerides (>800 mg/dL) or those with dysbetalipoproteinemia.

Q5: How often should LDL be monitored?
A: Frequency depends on individual risk factors and treatment goals, typically every 3-12 months during lipid-lowering therapy.