1. What is the Sampson Equation?

The Sampson equation is a novel method for calculating LDL cholesterol that provides more accurate results than traditional formulas, especially in patients with hypertriglyceridemia or diabetes.

2. How Does the Calculator Work?

The calculator uses the Sampson equation:

Where:

• \( TC \) — Total cholesterol (mg/dL)
• \( HDL-C \) — HDL cholesterol (mg/dL)
• \( TG \) — Triglycerides (mg/dL)

Explanation: This equation provides a more accurate estimation of LDL cholesterol compared to the traditional Friedewald formula, particularly when triglyceride levels are elevated.

3. Importance of LDL Calculation

Details: Accurate LDL cholesterol measurement is crucial for cardiovascular risk assessment, treatment decision-making, and monitoring response to lipid-lowering therapy.

4. Using the Calculator

Tips: Enter total cholesterol, HDL cholesterol, and triglycerides in mg/dL. All values must be valid and greater than 0.

5. Frequently Asked Questions (FAQ)

Q1: Why use Sampson equation instead of Friedewald formula?
A: The Sampson equation provides more accurate LDL calculations, especially when triglyceride levels are above 150 mg/dL or in diabetic patients.

Q2: What are optimal LDL levels?
A: Optimal LDL is generally <100 mg/dL, though target levels vary based on individual cardiovascular risk factors.

Q3: When should lipid measurements be taken?
A: Fasting samples (9-12 hours) are recommended for accurate triglyceride measurement, though non-fasting samples can be used for total and HDL cholesterol.

Q4: Are there limitations to this equation?
A: The equation may be less accurate in extreme lipid values or in certain medical conditions affecting lipid metabolism.

Q5: Can this calculator be used for treatment decisions?
A: While useful for estimation, clinical decisions should be based on direct LDL measurements when available, especially in high-risk patients.