1. What is the Sampson LDL Equation?

The Sampson equation is a novel method for calculating LDL cholesterol (LDL-C) directly from standard lipid panel measurements (total cholesterol, HDL cholesterol, and triglycerides). It provides a more accurate estimation than the traditional Friedewald formula, especially at lower LDL levels and higher triglyceride levels.

2. How Does the Calculator Work?

The calculator uses the Sampson equation:

Where:

• \( TC \) — Total cholesterol (mmol/L)
• \( HDL-C \) — HDL cholesterol (mmol/L)
• \( TG \) — Triglycerides (mmol/L)

Explanation: This equation provides a more accurate calculation of LDL cholesterol across a wider range of lipid values compared to traditional methods.

3. Importance of LDL-C Calculation

Details: Accurate LDL cholesterol measurement is crucial for cardiovascular risk assessment, treatment decisions, and monitoring the effectiveness of lipid-lowering therapies.

4. Using the Calculator

Tips: Enter total cholesterol, HDL cholesterol, and triglycerides in mmol/L. All values must be positive numbers. The calculator will provide the estimated LDL cholesterol value.

5. Frequently Asked Questions (FAQ)

Q1: Why use Sampson equation instead of Friedewald formula?
A: The Sampson equation provides more accurate LDL-C estimates, especially when triglycerides are elevated (>400 mg/dL or >4.5 mmol/L) or when LDL-C levels are low.

Q2: What are optimal LDL-C levels?
A: Optimal LDL-C is generally <2.6 mmol/L for most adults, and <1.8 mmol/L for high-risk patients, though targets may vary based on individual risk factors.

Q3: When should lipid measurements be taken?
A: Fasting samples (9-12 hours) are preferred for accurate triglyceride measurement, though non-fasting samples may be acceptable for some clinical purposes.

Q4: Are there limitations to this equation?
A: The equation may be less accurate in certain populations, such as those with very high triglycerides (>9.0 mmol/L) or unusual lipoprotein patterns.

Q5: Can this calculator be used for clinical decision making?
A: While this calculator provides estimates based on the Sampson equation, clinical decisions should be made in consultation with healthcare professionals using comprehensive patient assessment.