LDL Chol Calc NIH 150

NIH/Sampson Equation (for TG ≤ 150 mg/dL):

\[ LDL-C = \frac{TC}{0.948} - \frac{HDL-C}{0.971} - \left( \frac{TG}{8.56} + \frac{TG \times (TC - HDL-C)}{2140} - \frac{TG^2}{16100} \right) - 9.44 \]

Calculated LDL Cholesterol (LDL-C):

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1. What is the NIH/Sampson LDL Equation?

The NIH/Sampson equation is a novel method for calculating LDL cholesterol from standard lipid panel measurements (total cholesterol, HDL cholesterol, and triglycerides). It provides more accurate results than the traditional Friedewald formula, especially at triglyceride levels ≤150 mg/dL.

2. How Does the Calculator Work?

The calculator uses the NIH/Sampson equation:

\[ LDL-C = \frac{TC}{0.948} - \frac{HDL-C}{0.971} - \left( \frac{TG}{8.56} + \frac{TG \times (TC - HDL-C)}{2140} - \frac{TG^2}{16100} \right) - 9.44 \]

Where:

\( TC \) — Total cholesterol (mg/dL)
\( HDL-C \) — HDL cholesterol (mg/dL)
\( TG \) — Triglycerides (mg/dL) (must be ≤150 mg/dL)

Explanation: This equation uses multiple regression coefficients derived from large datasets to provide more accurate LDL-C estimation than traditional methods.

3. Importance of LDL Calculation

Details: Accurate LDL cholesterol measurement is crucial for cardiovascular risk assessment, treatment decision-making, and monitoring response to lipid-lowering therapy.

4. Using the Calculator

Tips: Enter total cholesterol, HDL cholesterol, and triglycerides (must be ≤150 mg/dL) in mg/dL. All values must be valid positive numbers.

5. Frequently Asked Questions (FAQ)

Q1: Why use NIH/Sampson instead of Friedewald formula?
A: The NIH/Sampson equation provides more accurate LDL-C estimation across various triglyceride levels and is less likely to underestimate LDL-C compared to the Friedewald formula.

Q2: What are the limitations of this equation?
A: This equation is specifically validated for triglyceride levels ≤150 mg/dL. For higher triglyceride levels, direct LDL measurement may be preferred.

Q3: When should this calculation be used?
A: This calculation is appropriate for routine clinical assessment of LDL cholesterol in patients with triglyceride levels ≤150 mg/dL.

Q4: Are there special preparation requirements?
A: Standard fasting lipid panel preparation applies - 9-12 hour fast, no alcohol for 24 hours, and stable weight for 2 weeks prior to testing.

Q5: How does this compare to direct LDL measurement?
A: This calculated method correlates well with direct measurement in most clinical situations and is more cost-effective for routine screening.