1. What is the Sampson LDL Equation?

The Sampson equation calculates LDL cholesterol (LDL-C) using total cholesterol, HDL cholesterol, and triglycerides. It provides more accurate results than the traditional Friedewald formula, especially when triglyceride levels are high.

2. How Does the Calculator Work?

The calculator uses the Sampson equation:

Where:

• \( TC \) — Total cholesterol (mg/dL)
• \( HDL-C \) — HDL cholesterol (mg/dL)
• \( TG \) — Triglycerides (mg/dL)

Explanation: This equation provides a more accurate calculation of LDL cholesterol, particularly in patients with high triglyceride levels where traditional formulas may be less reliable.

3. Importance of LDL Calculation

Details: Accurate LDL cholesterol measurement is crucial for cardiovascular risk assessment and guiding lipid-lowering therapy decisions.

4. Using the Calculator

Tips: Enter total cholesterol, HDL cholesterol, and triglycerides in mg/dL. All values must be valid positive numbers.

5. Frequently Asked Questions (FAQ)

Q1: Why use Sampson equation instead of Friedewald?
A: The Sampson equation provides more accurate LDL calculations when triglyceride levels are elevated (>200 mg/dL) or in non-fasting conditions.

Q2: What are optimal LDL levels?
A: Optimal LDL is generally <100 mg/dL, though targets may vary based on individual cardiovascular risk factors.

Q3: When should this equation be used?
A: Particularly useful when triglyceride levels are between 200-800 mg/dL, where traditional formulas may underestimate LDL.

Q4: Are there limitations to this equation?
A: The equation may be less accurate with extremely high triglyceride levels (>800 mg/dL) or in certain patient populations.

Q5: Is fasting required for accurate results?
A: While fasting samples are ideal, the Sampson equation can provide reasonable estimates from non-fasting samples.