Friedewald Equation:
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The Friedewald equation is a formula used to estimate LDL cholesterol levels from measured values of total cholesterol, HDL cholesterol, and triglycerides. It provides a calculated LDL value without requiring direct measurement.
The calculator uses the Friedewald equation:
Where:
Explanation: The equation estimates LDL cholesterol by subtracting HDL and VLDL (estimated as TG/5) from total cholesterol.
Details: LDL cholesterol is a major risk factor for cardiovascular disease. Monitoring LDL levels helps assess cardiovascular risk and guide treatment decisions for cholesterol management.
Tips: Enter total cholesterol, HDL cholesterol, and triglycerides in mg/dL. All values must be valid (greater than 0). Note: This equation is not accurate when triglyceride levels exceed 400 mg/dL.
Q1: When is the Friedewald equation not accurate?
A: The equation becomes less accurate when triglyceride levels are above 400 mg/dL, in non-fasting samples, or in patients with certain metabolic disorders.
Q2: What are optimal LDL cholesterol levels?
A: Optimal LDL is generally below 100 mg/dL, though targets may vary based on individual cardiovascular risk factors.
Q3: How should blood samples be collected for accurate results?
A: Fasting for 9-12 hours is recommended for accurate lipid panel measurements, including triglyceride levels.
Q4: Are there alternative methods for LDL measurement?
A: Yes, direct LDL measurement is available and may be more accurate in certain situations, particularly when triglycerides are elevated.
Q5: How often should LDL cholesterol be checked?
A: Frequency depends on individual risk factors, but generally every 4-6 years for adults with normal levels, and more frequently for those with elevated levels or on treatment.