Friedewald Formula:
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The Friedewald formula is a widely used equation to estimate LDL cholesterol (LDL-C) levels from measurements of total cholesterol, HDL cholesterol, and triglycerides. It provides a calculated LDL value without requiring direct measurement.
The calculator uses the Friedewald formula:
Where:
Explanation: The formula estimates LDL cholesterol by subtracting HDL cholesterol and one-fifth of triglycerides from total cholesterol.
Details: LDL cholesterol is a major risk factor for cardiovascular disease. Accurate estimation helps assess cardiovascular risk and guide treatment decisions, particularly cholesterol-lowering therapy.
Tips: Enter total cholesterol, HDL cholesterol, and triglycerides in mg/dL. All values must be valid (greater than 0). For accurate results, measurements should be taken from a fasting blood sample.
Q1: When is the Friedewald formula not accurate?
A: The formula is less accurate when triglyceride levels are above 400 mg/dL, in non-fasting samples, or in patients with certain metabolic disorders.
Q2: What are optimal LDL cholesterol levels?
A: Optimal LDL levels are generally below 100 mg/dL, though targets may vary based on individual cardiovascular risk factors.
Q3: How often should cholesterol be measured?
A: Adults should have cholesterol checked every 4-6 years, or more frequently if risk factors are present or treatment is initiated.
Q4: Are there alternatives to the Friedewald formula?
A: Yes, direct LDL measurement or the Martin/Hopkins method may be used, especially when triglycerides are elevated.
Q5: Should this calculation be used for everyone?
A: While useful for most people, those with very high triglycerides, certain genetic disorders, or unusual lipoprotein patterns may require direct measurement.